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Shiga toxin-associated hemolytic uremic syndrome

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Disease definition

A rare thrombotic microangiopathy characterized by mechanical hemolytic anemia, thrombocytopenia, and renal dysfunction that is usually associated with prodromal enteritis caused by Shigella dysentriae type 1 or E. Coli.

ORPHA:90038

Classification level: Subtype of disorder

Synonym(s):
  • Typical HUS
  • Typical hemolytic uremic syndrome
  • Shiga-like toxin-associated HUS
  • D+ HUS
  • Stx-HUS
  • Hemolytic uremic syndrome with diarrhea
  • Hemolytic uremic syndrome associated with Shiga toxin-producing Escherichia coli
  • STEC-HUS
  • EHEC-HUS

Prevalence: Unknown

Inheritance: Not applicable

Age of onset: All ages

ICD-10: D58.8

ICD-11: XN108 3A21.Y

OMIM: 235400

UMLS: C1268936

A summary on this disease is available in Français, Español, Deutsch, Italiano, Nederlands, Polski
Detailed information

Logo ERN: produced/endorsed by ERN(s) Logo FSMR: produced/endorsed by FSMR(s)

General public
Article for general public
Français (2015) - Minist Santé et Prévention
Guidelines
Emergency guidelines
Français (2021.pdf) - Orphanet Urgences
Clinical practice guidelines
Disease review articles
Review article
English (2012) - Nephrol Dial Transplant
Diagnostic Keys
Français (2025) - Les clés du diagnostic Logo FSMR
The documents contained in this website are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.