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Toxic epidermal necrolysis
An extended form of Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum characterized by destruction and detachment of the skin epithelium, involving 30% or more of the body surface area, and mucous membranes. Onset usually occurs 4-28 days after administration of the causal medication and is most frequently associated with anticonvulsants, antibacterial sulfonamides, allopurinol, nevirapine, and oxicams (non-steroidal anti-inflammatory drugs), but many other medications have also been implicated. The disease is not induced by medication in 15% of cases. Histology is characterized by an epidermal necrolysis. Multiple disabling long-term sequelae (especially cutaneous, ocular and psychological) are frequent.
ORPHA:537
Classification level: Subtype of disorder
- Lyell syndrome
Prevalence: Unknown
Inheritance: Not applicable
Age of onset: All ages
: produced/endorsed by ERN(s)
: produced/endorsed by FSMR(s)
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