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Exercise-induced malignant hyperthermia

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Disease definition

A rare disease with malignant hyperthermia characterized by exercise-induced life-threatening hyperthermia with a body temperature over 40°C and signs of encephalopathy ranging from confusion to convulsions or coma. Incidence increases with rising ambient temperature and relative humidity. Manifestations may include rhabdomyolysis (presenting with myalgia, muscle weakness, and myoglobinuria), tachycardia, and in severe cases multiorgan failure.

ORPHA:466650

Classification level: Disorder

Synonym(s):
  • Exertional heat stroke

Source: PubMed ID 22538307 23476141

Prevalence: Unknown

Inheritance: Multigenic/multifactorial

Age of onset: All ages

ICD-10: T88.3

ICD-11: NF06.0

UMLS: C5700399

A summary on this disease is available in Français, Español, Deutsch, Italiano, Nederlands
Detailed information

Logo ERN: produced/endorsed by ERN(s) Logo FSMR: produced/endorsed by FSMR(s)

Guidelines
Emergency guidelines
Français (2017.pdf) - Orphanet Urgences
Español (2018.pdf) - Orphanet Urgences
Disease review articles
Review article
English (2015) - Orphanet J Rare Dis
The documents contained in this website are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.