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Idiopathic/heritable pulmonary arterial hypertension

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Disease definition

A form of pulmonary arterial hypertension (PAH) characterized by elevated pulmonary arterial resistance leading to right heart failure; it is progressive and potentially fatal. The majority cases have an identifiable genetic cause, but a significant proportion are idiopathic.

ORPHA:422

Classification level: Disorder

Synonym(s):
  • Idiopathic and/or familial pulmonary arterial hypertension

Source: PubMed ID 35412560 36179740 32671468

Prevalence: 1-9 / 100 000

Inheritance: Autosomal dominant, Autosomal recessive, Not applicable

Age of onset: All ages

ICD-10: I27.0

ICD-11: BB01.0

OMIM: 178600 265400 615342 615343 615344

UMLS: C5679820

A summary on this disease is available in Français, Español, Deutsch, Italiano, Nederlands, Polski Slovenčina
Detailed information

Logo ERN: produced/endorsed by ERN(s) Logo FSMR: produced/endorsed by FSMR(s)

General public
Guidelines
Emergency guidelines
Français (2020.pdf) - Orphanet Urgences
Clinical practice guidelines
English (2023) - Eur J Heart Fail Logo ERN
English (2022) - Eur Heart J Logo ERN
English (2011) - Int J Cardiol Logo ERN
English (2016) - Eur Heart J Logo ERN
Disease review articles
Review article
English (2013) - Orphanet J Rare Dis
Clinical genetics review
English (2020) - GeneReviews
Genetic testing
Guidance for genetic testing
Patient-Centered Outcome Measures (PCOMs)
Access questionnaires assessing quality of life in this disease (English)
The documents contained in this website are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.