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Hyperammonemic encephalopathy due to carbonic anhydrase VA deficiency

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Disease definition

A rare, hereditary inborn error of metabolism characterized by an acute onset of encephalopathy in infancy or early childhood. Apart from these episodic acute events, the disorder shows a relatively benign course. Multiple metabolic abnormalities are present, including metabolic acidosis, respiratory alkalosis, hypoglycemia, increased serum lactate and alanine.

ORPHA:401948

Classification level: Disorder

Synonym(s):
  • CA-VA deficiency

Prevalence: <1 / 1 000 000

Inheritance: Autosomal recessive

Age of onset: Childhood, Infancy, Neonatal

ICD-10: E74.8

OMIM: 615751

UMLS: C4706871

GARD: 13201

A summary on this disease is available in Français, Español, Deutsch, Italiano, Nederlands
Detailed information

Logo ERN: produced/endorsed by ERN(s) Logo FSMR: produced/endorsed by FSMR(s)

Guidelines
Emergency guidelines
Clinical practice guidelines
Disease review articles
Clinical genetics review
English (2021) - GeneReviews
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