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Glycogen storage disease with severe cardiomyopathy due to glycogenin deficiency

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Disease definition

A rare autosomal recessive glycogen storage disease characterized by severe cardiomyopathy and cardiac dilatation potentially progressing to heart failure requiring transplantation. Cardiomyocytes show large inclusions of storage material consistent with polyglucosan. Clinical evidence of skeletal muscle involvement is usually absent.

ORPHA:263297

Classification level: Disorder

Synonym(s):
  • GSD type 15
  • GSD type XV
  • GSD with severe cardiomyopathy due to glycogenin deficiency
  • Glycogen storage disease type 15
  • Glycogen storage disease type XV
  • Glycogenosis type 15
  • Glycogenosis type XV
  • Glycogenosis with severe cardiomyopathy due to glycogenin deficiency

Prevalence: <1 / 1 000 000

Inheritance: Autosomal recessive

Age of onset: Childhood

ICD-10: E74.0

ICD-11: 5C51.3

OMIM: 613507

UMLS: C4303568

A summary on this disease is available in Français, Español, Deutsch, Italiano, Português, Nederlands, Polski
Detailed information

Logo ERN: produced/endorsed by ERN(s) Logo FSMR: produced/endorsed by FSMR(s)

Guidelines
Emergency guidelines
Français (2018.pdf) - Orphanet Urgences
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